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PHARMACEUTICAL INORGANIC CHEMISTRY (THEORY)



UNIT I




1. Impurities in pharmaceutical substances











UNIT II



1. Acids, Bases and Buffers






UNIT III






UNIT IV



1. Miscellaneous compounds




UNIT V




1. Radiopharmaceuticals





UNIT I

• Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate


General methods of preparation, assay for the compounds superscripted with asterisk (*), properties and medicinal uses of inorganic compounds belonging to the following classes


UNIT II

• Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.


• Major extra and intracellular electrolytes: Functions of major physiological ions, Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base balance.


• Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.


UNIT III

• Gastrointestinal agents

Acidifiers: Ammonium chloride* and Dil. HCl


Antacid: Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture


Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite


Antimicrobials: Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide*, Chlorinated lime*, Iodine and its preparations


UNIT IV


• Miscellaneous compounds


Expectorants: Potassium iodide, Ammonium chloride*.


Emetics: Copper sulphate*, Sodium potassium tartarate


Haematinics: Ferrous sulphate*, Ferrous gluconate


Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite


Astringents: Zinc Sulphate, Potash Alum


UNIT V

• Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations, Half life, radio isotopes and study of radio isotopes - Sodium iodide I131, Storage conditions, precautions & pharmaceutical application of radioactive substances.


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#pharmacy #pharmaceuticalinorganicchemistry #inorganicchemistry






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